CAS:
CAS：941987-60-6
货号：H3676
储存条件：粉末-20°C可保存3年；液体-80°C可保存12月。
产品描述
H-151 is a potent and selective STING antagonist. It dose-dependently abrogated IFNβ luciferase reporter at concentration ranging in 0.02-2μM in HEK293T cells. It reduced TBK1 phosphorylation (0.5μM, for 2h) in THP-1 cells and suppression of hsSTING palmitoylation (1μM, for 3h) without affecting respective controls. Pre-treatment of H-151 markedly reduced systemic cytokine responses in CMA (STING agonist)-treated mice.
作用机制
H-151 can bind covalently with Cys91 of hsSTING.
产品信息
CAS号 | 941987-60-6 | |
分子式 | C17H17N3O | |
分子量 | 279.34 | |
溶解度
| DMSO | 230.0 mg/mL (823.4 mM) |
Water | insoluble | |
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