货号：A6436

储存条件：粉末-20°C可保存3年；液体-80°C可保存12月。

产品描述

Acetylcysteine is a thiol-containing antioxidant that has been shown to inhibit the binding activity of NF-κB in response to multiple agonists in various cell types. Preincubation of human umbilical vein endothelial cells with acetylcysteine (0 – 40mM) for 1h dose-dependently inhibited IL-1b-induced monocytic cell adhesion. The IC50 value of acetylcysteine was 20mM, and the 95% inhibition was observed at 40mM. Acetylcysteine treatment also resulted in a reduction in surface expression of E-selectin and VCAM-1 of 56% and 70%, respectively, in endothelial cells. In addition, acetylcysteine promoted long-term survival of serum-deprived PC12 cells with an ED50 value of around 30nM. It dose-dependently prevented internucleosomal DNA cleavage at the doses of 10 – 80mM. The presence of acetylcysteine also promoted the survival of neonatal rat sympathetic neurons. In PC12 cells, the thymidine incorporation and proliferation were almost completely blocked by 60mM acetylcysteine with an ED50 value of approximately 30mM. Administration of SAMP8 mice with acetylcysteine (100mg/kg, once daily, s.c.) for four weeks improved their cognition in both the T‐maze footshock avoidance paradigm and the lever press appetitive task when compared to mice treated with saline.

作用机制

Acetylcysteine is a thiol and mucolytic agent that acts as an antioxidant by maintaining the balance of intracellular glutathione. The free sulfhydryl group allows acetylcysteine to reduce disulphide bonds, thereby decreasing mucus viscosity and facilitating mucociliary clearance.

产品信息