货号：S8744
储存条件：粉末-20°C可保存3年；液体-80°C可保存12月。
产品描述
Human neutrophil elastase (HNE) is a protease that participates in tissue injuries of emphysema, rheumatoid arthritis, and septic shock. Sivelestat is a potent, selective, intravenously active HNE inhibitor with an IC50 value of 44±3nM and a Ki value of 200±20nM. It also inhibited leukocyte elastase obtained from rabbits, rats, hamsters, and mice with IC50 values of 36±1, 19±1, 37±4, and 49±5nM, respectively. Sivelestat inhibited porcine pancreas elastase with an IC50 value of 5.6±0.2μM. Intratracheal administration of sivelestat dose-dependently suppressed lung hemorrhage in hamsters with an ID50 value of 82μg/kg. In Guinea pigs, intravenous administration of sivelestat significantly and dose-dependently suppressed HNE-induced increase in skin capillary permeability with an ID50 value of 9.6mg/kg. In rats, intravenous injection of sivelestat at a dosage of 10mg/kg significantly ameliorated lung injury induced by hemorrhagic shock followed by resuscitation.
储存液制备 | 质量 | 1 mg | 5 mg | 10 mg |
1 mM | 2.3017 mL | 11.5085 mL | 23.0169 mL | |
5 mM | 0.4603 mL | 2.3017 mL | 4.6034 mL | |
10 mM | 0.2302 mL | 1.1508 mL | 2.3017 mL |
产品信息
CAS号 | 127373-66-4 | |
分子式 | C20H22N2O7S | |
分子量 | 434.46 | |
溶解度
| DMSO | 83.0 mg/mL (191.0 mM) |
Water | lnsoluble | |
Ethanol | 83.0 mg/mL (191.0 mM) | |
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