货号：R9418

储存条件：粉末-20°C可保存3年；液体-80°C可保存12月。 

产品描述

Retinoic acid receptors (RARs) are members of the super‐family of nuclear hormone receptors, which directly regulate the transcription of their target genes in the nucleus. Retinoic acid, the active metabolite of vitamin A, is a ligand for retinoic acid receptor (RAR) and retinoid X receptor (RXR). It has pleiotropic effects on growth, differentiation, proliferation, and development, and determines embryonic pattern formation and inhibits tumor growth. Addition of tretinoin significantly suppressed the remarkably elevated MMP-13 mRNA expression in the keloid‐derived dermal fibroblasts, with the peak suppression at 12h. Tretinoin also prevented the cytotoxicity of H2O2 in cultured human mesangial cells by increasing both the catalase activity and the reduced glutathione content in dose- and time-dependent manner. Retinoic acid at 10 μM inhibited the migration of Aspc-1 and Panc-1 cells indirectly through its inhibitory effects on cancer associated fibroblasts (CAFs) and inhibited epithelial-mesenchymal transition of tumor cells by decreasing IL-6 secretion of CAFs. Neural stem cells (NSCs) treated with 1 µM retinoic acid for 4 days showed increased HRas and Tuj1 levels together with the increase in the active HRas level, which was required for NSC differentiation into neurons and murine brain development.

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