货号：E7148

储存条件：粉末-20°C可保存3年；液体-80°C可保存12月。

产品描述

Erastin is a both Ferroptosis activator and mitochondrial VDAC modulator. Erastin can trigger ferroptosis dependent upon intracellular iron. Treatment with 10μM Erastin for 6h can induce accumulation of cytosolic ROS which can be inhibited by 100μM deferoxamine in HT-1080 cells. Iron-dependent oxidative death and inhibition of System x-c can also be observed. Erastin can induce rapid, oxidative, non-apoptotic death in HRASV12-expressing cell lines at concentration below 1μM. This lethal effect of erastin is dependent on the RAS–RAF–MEK pathway for inhibition of MAPK, ERK1/ 2 or MEK1/2, or KRAS and BRAF knockdown could restore the lethality of erastin. This selectivity for cells with activated RAS–RAF–MEK signaling may due to the interaction of Erastin with VDAC proteins and the subsequent induction of mitochondrial dysfunction, release of oxidative species and, ultimately, non-apoptotic, oxidative cell death.

产品信息