货号：E6836

储存条件：粉末-20°C可保存3年；液体-80°C可保存12月。

产品描述

Epigallocatechin-3-gallate (EGCG), also termed Epigallocatechol Gallate, the most abundant and most biologically active catechin from green tea, is a potential therapeutic agent for preventing neurodegenerative, inflammatory diseases and cancer. In vitro EGCG supplementation dose-dependently reduced neutrophil migration induced by chemokine interleukin (IL)-8 with an IC₅₀ lower than 1 mM and by cytokine-induced neutrophil chemoattractant-1 at a dose of 15 mg/ml or higher. PC12 cells cultured without serum were administrated with EGCG (0.1 and 1 μM) for 24h which resulted in improved cell morphology and promoted neurite outgrowth, and significant lower cell mortality as compared with serum free group (~40%). There was a gradual increase in neurite length after exposure to EGCG (0.1 and 1 μM); at 4 days of EGCG (1 μM) treatment 40 ± 0.9 and 25.2 ± 2.2% of detected cells exhibited extended neurites, respectively. EGCG decreased cell viability as concentration- and time-dependently, with IC₅₀ values of 14.17 µM for human breast cancer cell line T47D and 193.10 µM for normal human foreskin fibroblast cell line HFF cells, through down-regulation of PI3K/AKT and telomerase.

产品信息